CovidStanfordV1, Main, Exploration, bibRecord, 000418

Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study.

Identifieur interne : 000418 ( Main/Exploration ); précédent : 000417; suivant : 000419

Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study.

Auteurs : Thomas Marjot [Royaume-Uni] ; Andrew M. Moon [États-Unis] ; Jonathan A. Cook [Royaume-Uni] ; Sherief Abd-Elsalam [Égypte] ; Costica Aloman [États-Unis] ; Matthew J. Armstrong [Royaume-Uni] ; Elisa Pose [Espagne] ; Erica J. Brenner [États-Unis] ; Tamsin Cargill [Royaume-Uni] ; Maria-Andreea Catana [États-Unis] ; Renumathy Dhanasekaran [États-Unis] ; Ahad Eshraghian [Iran] ; Ignacio García-Juárez [Mexique] ; Upkar S. Gill [Royaume-Uni] ; Patricia D. Jones [États-Unis] ; James Kennedy [Royaume-Uni] ; Aileen Marshall [Royaume-Uni] ; Charmaine Matthews [Royaume-Uni] ; George Mells [Royaume-Uni] ; Carolyn Mercer [Royaume-Uni] ; Ponni V. Perumalswami [États-Unis] ; Emma Avitabile [Espagne] ; Xialong Qi [République populaire de Chine] ; Feng Su [États-Unis] ; Nneka N. Ufere [États-Unis] ; Yu Jun Wong [Singapour] ; Ming-Hua Zheng [République populaire de Chine] ; Eleanor Barnes [Royaume-Uni] ; Alfred S. Barritt [États-Unis] ; Gwilym J. Webb [Royaume-Uni]

Source :

Journal of hepatology [ 1600-0641 ] ; 2020.

RBID : pubmed:33035628

Abstract

BACKGROUND & AIMS

Chronic liver disease (CLD) and cirrhosis are associated with immune dysregulation, leading to concerns that affected patients may be at risk of adverse outcomes following SARS-CoV-2 infection. We aimed to determine the impact of COVID-19 on patients with pre-existing liver disease, which currently remains ill-defined.

METHODS

Between 25th March and 8th July 2020, data on 745 patients with CLD and SARS-CoV-2 (including 386 with and 359 without cirrhosis) were collected by 2 international registries and compared to data on non-CLD patients with SARS-CoV-2 from a UK hospital network.

RESULTS

Mortality was 32% in patients with cirrhosis compared to 8% in those without (p <0.001). Mortality in patients with cirrhosis increased according to Child-Pugh class (A [19%], B [35%], C [51%]) and the main cause of death was from respiratory failure (71%). After adjusting for baseline characteristics, factors associated with death in the total CLD cohort were age (odds ratio [OR] 1.02; 1.01-1.04), Child-Pugh A (OR 1.90; 1.03-3.52), B (OR 4.14; 2.4-7.65), or C (OR 9.32; 4.80-18.08) cirrhosis and alcohol-related liver disease (OR 1.79; 1.03-3.13). Compared to patients without CLD (n = 620), propensity-score-matched analysis revealed significant increases in mortality in those with Child-Pugh B (+20.0% [8.8%-31.3%]) and C (+38.1% [27.1%-49.2%]) cirrhosis. Acute hepatic decompensation occurred in 46% of patients with cirrhosis, of whom 21% had no respiratory symptoms. Half of those with hepatic decompensation had acute-on-chronic liver failure.

CONCLUSIONS

In the largest such cohort to date, we demonstrate that baseline liver disease stage and alcohol-related liver disease are independent risk factors for death from COVID-19. These data have important implications for the risk stratification of patients with CLD across the globe during the COVID-19 pandemic.

LAY SUMMARY

This international registry study demonstrates that patients with cirrhosis are at increased risk of death from COVID-19. Mortality from COVID-19 was particularly high among patients with more advanced cirrhosis and those with alcohol-related liver disease.

DOI: 10.1016/j.jhep.2020.09.024
PubMed: 33035628
PubMed Central: PMC7536538

Affiliations:

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</author>
<author><name sortKey="Moon, Andrew M" sort="Moon, Andrew M" uniqKey="Moon A" first="Andrew M" last="Moon">Andrew M. Moon</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, University of North Carolina, North Carolina, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology and Hepatology, University of North Carolina, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cook, Jonathan A" sort="Cook, Jonathan A" uniqKey="Cook J" first="Jonathan A" last="Cook">Jonathan A. Cook</name>
<affiliation wicri:level="4"><nlm:affiliation>Centre for Statistics in Medicine, University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Statistics in Medicine, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Abd Elsalam, Sherief" sort="Abd Elsalam, Sherief" uniqKey="Abd Elsalam S" first="Sherief" last="Abd-Elsalam">Sherief Abd-Elsalam</name>
<affiliation wicri:level="1"><nlm:affiliation>Tropical Medicine and Infectious diseases Department, Tanta University, Tanta, Egypt.</nlm:affiliation>
<country xml:lang="fr">Égypte</country>
<wicri:regionArea>Tropical Medicine and Infectious diseases Department, Tanta University, Tanta</wicri:regionArea>
<wicri:noRegion>Tanta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aloman, Costica" sort="Aloman, Costica" uniqKey="Aloman C" first="Costica" last="Aloman">Costica Aloman</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Section of Hepatology, Rush University Medical Center, Chicago, Illinois, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Section of Hepatology, Rush University Medical Center, Chicago, Illinois</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Armstrong, Matthew J" sort="Armstrong, Matthew J" uniqKey="Armstrong M" first="Matthew J" last="Armstrong">Matthew J. Armstrong</name>
<affiliation wicri:level="3"><nlm:affiliation>Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham</wicri:regionArea>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pose, Elisa" sort="Pose, Elisa" uniqKey="Pose E" first="Elisa" last="Pose">Elisa Pose</name>
<affiliation wicri:level="3"><nlm:affiliation>Liver Unit, Hospital Clínic, Barcelona, Spain Institut d'Investigacions Biomèdiques, August Pi i Sunyer, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Liver Unit, Hospital Clínic, Barcelona, Spain Institut d'Investigacions Biomèdiques, August Pi i Sunyer, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brenner, Erica J" sort="Brenner, Erica J" uniqKey="Brenner E" first="Erica J" last="Brenner">Erica J. Brenner</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Pediatric Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Pediatric Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cargill, Tamsin" sort="Cargill, Tamsin" uniqKey="Cargill T" first="Tamsin" last="Cargill">Tamsin Cargill</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Catana, Maria Andreea" sort="Catana, Maria Andreea" uniqKey="Catana M" first="Maria-Andreea" last="Catana">Maria-Andreea Catana</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology/Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology/Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dhanasekaran, Renumathy" sort="Dhanasekaran, Renumathy" uniqKey="Dhanasekaran R" first="Renumathy" last="Dhanasekaran">Renumathy Dhanasekaran</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Palo Alto, California, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Palo Alto, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eshraghian, Ahad" sort="Eshraghian, Ahad" uniqKey="Eshraghian A" first="Ahad" last="Eshraghian">Ahad Eshraghian</name>
<affiliation wicri:level="1"><nlm:affiliation>Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz</wicri:regionArea>
<wicri:noRegion>Shiraz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Garcia Juarez, Ignacio" sort="Garcia Juarez, Ignacio" uniqKey="Garcia Juarez I" first="Ignacio" last="García-Juárez">Ignacio García-Juárez</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.</nlm:affiliation>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City</wicri:regionArea>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gill, Upkar S" sort="Gill, Upkar S" uniqKey="Gill U" first="Upkar S" last="Gill">Upkar S. Gill</name>
<affiliation wicri:level="3"><nlm:affiliation>Barts Liver Centre, Barts Health NHS Trust & Barts & The London School of Medicine & Dentistry, QMUL, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Barts Liver Centre, Barts Health NHS Trust & Barts & The London School of Medicine & Dentistry, QMUL, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jones, Patricia D" sort="Jones, Patricia D" uniqKey="Jones P" first="Patricia D" last="Jones">Patricia D. Jones</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Digestive Health and Liver Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Digestive Health and Liver Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kennedy, James" sort="Kennedy, James" uniqKey="Kennedy J" first="James" last="Kennedy">James Kennedy</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marshall, Aileen" sort="Marshall, Aileen" uniqKey="Marshall A" first="Aileen" last="Marshall">Aileen Marshall</name>
<affiliation wicri:level="3"><nlm:affiliation>Sheila Sherlock Liver Unit, Royal Free Hospital, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sheila Sherlock Liver Unit, Royal Free Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Matthews, Charmaine" sort="Matthews, Charmaine" uniqKey="Matthews C" first="Charmaine" last="Matthews">Charmaine Matthews</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Royal Liverpool Hospital, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Royal Liverpool Hospital, Liverpool University Hospitals NHS Foundation Trust, Liverpool</wicri:regionArea>
<wicri:noRegion>Liverpool</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mells, George" sort="Mells, George" uniqKey="Mells G" first="George" last="Mells">George Mells</name>
<affiliation wicri:level="1"><nlm:affiliation>Cambridge Liver Unit, Addenbrooke's Hospital, Cambridge University Hospitals, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cambridge Liver Unit, Addenbrooke's Hospital, Cambridge University Hospitals, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mercer, Carolyn" sort="Mercer, Carolyn" uniqKey="Mercer C" first="Carolyn" last="Mercer">Carolyn Mercer</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perumalswami, Ponni V" sort="Perumalswami, Ponni V" uniqKey="Perumalswami P" first="Ponni V" last="Perumalswami">Ponni V. Perumalswami</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Avitabile, Emma" sort="Avitabile, Emma" uniqKey="Avitabile E" first="Emma" last="Avitabile">Emma Avitabile</name>
<affiliation wicri:level="3"><nlm:affiliation>Liver Unit, Hospital Clínic, Barcelona, Spain Institut d'Investigacions Biomèdiques, August Pi i Sunyer, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Liver Unit, Hospital Clínic, Barcelona, Spain Institut d'Investigacions Biomèdiques, August Pi i Sunyer, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Qi, Xialong" sort="Qi, Xialong" uniqKey="Qi X" first="Xialong" last="Qi">Xialong Qi</name>
<affiliation wicri:level="1"><nlm:affiliation>CHESS Center, Institute of Portal Hypertension, The First Hospital of Lanzhou University, Lanzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CHESS Center, Institute of Portal Hypertension, The First Hospital of Lanzhou University, Lanzhou</wicri:regionArea>
<wicri:noRegion>Lanzhou</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Su, Feng" sort="Su, Feng" uniqKey="Su F" first="Feng" last="Su">Feng Su</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Gastroenterology, University of Washington, Seattle, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology, University of Washington, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Ufere, Nneka N" sort="Ufere, Nneka N" uniqKey="Ufere N" first="Nneka N" last="Ufere">Nneka N. Ufere</name>
<affiliation wicri:level="2"><nlm:affiliation>Liver Center, Gastrointestinal Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Liver Center, Gastrointestinal Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wong, Yu Jun" sort="Wong, Yu Jun" uniqKey="Wong Y" first="Yu Jun" last="Wong">Yu Jun Wong</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Gastroenterology & Hepatology, Changi General Hospital Yong Loo Lin School of Medicine, National University of Singapore, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Department of Gastroenterology & Hepatology, Changi General Hospital Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
</author>
<author><name sortKey="Zheng, Ming Hua" sort="Zheng, Ming Hua" uniqKey="Zheng M" first="Ming-Hua" last="Zheng">Ming-Hua Zheng</name>
<affiliation wicri:level="1"><nlm:affiliation>MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease, Zhejiang Province, Wenzhou, Zhejiang, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease, Zhejiang Province, Wenzhou, Zhejiang</wicri:regionArea>
<wicri:noRegion>Zhejiang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barnes, Eleanor" sort="Barnes, Eleanor" uniqKey="Barnes E" first="Eleanor" last="Barnes">Eleanor Barnes</name>
<affiliation wicri:level="3"><nlm:affiliation>Oxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barritt, Alfred S" sort="Barritt, Alfred S" uniqKey="Barritt A" first="Alfred S" last="Barritt">Alfred S. Barritt</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, University of North Carolina, North Carolina, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology and Hepatology, University of North Carolina, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Webb, Gwilym J" sort="Webb, Gwilym J" uniqKey="Webb G" first="Gwilym J" last="Webb">Gwilym J. Webb</name>
<affiliation wicri:level="1"><nlm:affiliation>Oxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK; Cambridge Liver Unit, Addenbrooke's Hospital, Cambridge University Hospitals, Cambridge, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK; Cambridge Liver Unit, Addenbrooke's Hospital, Cambridge University Hospitals, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of hepatology</title>
<idno type="eISSN">1600-0641</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
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<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND & AIMS</b>
</p>
<p>Chronic liver disease (CLD) and cirrhosis are associated with immune dysregulation, leading to concerns that affected patients may be at risk of adverse outcomes following SARS-CoV-2 infection. We aimed to determine the impact of COVID-19 on patients with pre-existing liver disease, which currently remains ill-defined.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Between 25th March and 8th July 2020, data on 745 patients with CLD and SARS-CoV-2 (including 386 with and 359 without cirrhosis) were collected by 2 international registries and compared to data on non-CLD patients with SARS-CoV-2 from a UK hospital network.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Mortality was 32% in patients with cirrhosis compared to 8% in those without (p <0.001). Mortality in patients with cirrhosis increased according to Child-Pugh class (A [19%], B [35%], C [51%]) and the main cause of death was from respiratory failure (71%). After adjusting for baseline characteristics, factors associated with death in the total CLD cohort were age (odds ratio [OR] 1.02; 1.01-1.04), Child-Pugh A (OR 1.90; 1.03-3.52), B (OR 4.14; 2.4-7.65), or C (OR 9.32; 4.80-18.08) cirrhosis and alcohol-related liver disease (OR 1.79; 1.03-3.13). Compared to patients without CLD (n = 620), propensity-score-matched analysis revealed significant increases in mortality in those with Child-Pugh B (+20.0% [8.8%-31.3%]) and C (+38.1% [27.1%-49.2%]) cirrhosis. Acute hepatic decompensation occurred in 46% of patients with cirrhosis, of whom 21% had no respiratory symptoms. Half of those with hepatic decompensation had acute-on-chronic liver failure.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>In the largest such cohort to date, we demonstrate that baseline liver disease stage and alcohol-related liver disease are independent risk factors for death from COVID-19. These data have important implications for the risk stratification of patients with CLD across the globe during the COVID-19 pandemic.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>LAY SUMMARY</b>
</p>
<p>This international registry study demonstrates that patients with cirrhosis are at increased risk of death from COVID-19. Mortality from COVID-19 was particularly high among patients with more advanced cirrhosis and those with alcohol-related liver disease.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33035628</PMID>
<DateRevised><Year>2021</Year>
<Month>01</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-0641</ISSN>
<JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year>
<Month>Oct</Month>
<Day>06</Day>
</PubDate>
</JournalIssue>
<Title>Journal of hepatology</Title>
<ISOAbbreviation>J Hepatol</ISOAbbreviation>
</Journal>
<ArticleTitle>Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">S0168-8278(20)33667-9</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jhep.2020.09.024</ELocationID>
<Abstract><AbstractText Label="BACKGROUND & AIMS" NlmCategory="OBJECTIVE">Chronic liver disease (CLD) and cirrhosis are associated with immune dysregulation, leading to concerns that affected patients may be at risk of adverse outcomes following SARS-CoV-2 infection. We aimed to determine the impact of COVID-19 on patients with pre-existing liver disease, which currently remains ill-defined.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Between 25th March and 8th July 2020, data on 745 patients with CLD and SARS-CoV-2 (including 386 with and 359 without cirrhosis) were collected by 2 international registries and compared to data on non-CLD patients with SARS-CoV-2 from a UK hospital network.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Mortality was 32% in patients with cirrhosis compared to 8% in those without (p <0.001). Mortality in patients with cirrhosis increased according to Child-Pugh class (A [19%], B [35%], C [51%]) and the main cause of death was from respiratory failure (71%). After adjusting for baseline characteristics, factors associated with death in the total CLD cohort were age (odds ratio [OR] 1.02; 1.01-1.04), Child-Pugh A (OR 1.90; 1.03-3.52), B (OR 4.14; 2.4-7.65), or C (OR 9.32; 4.80-18.08) cirrhosis and alcohol-related liver disease (OR 1.79; 1.03-3.13). Compared to patients without CLD (n = 620), propensity-score-matched analysis revealed significant increases in mortality in those with Child-Pugh B (+20.0% [8.8%-31.3%]) and C (+38.1% [27.1%-49.2%]) cirrhosis. Acute hepatic decompensation occurred in 46% of patients with cirrhosis, of whom 21% had no respiratory symptoms. Half of those with hepatic decompensation had acute-on-chronic liver failure.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In the largest such cohort to date, we demonstrate that baseline liver disease stage and alcohol-related liver disease are independent risk factors for death from COVID-19. These data have important implications for the risk stratification of patients with CLD across the globe during the COVID-19 pandemic.</AbstractText>
<AbstractText Label="LAY SUMMARY" NlmCategory="UNASSIGNED">This international registry study demonstrates that patients with cirrhosis are at increased risk of death from COVID-19. Mortality from COVID-19 was particularly high among patients with more advanced cirrhosis and those with alcohol-related liver disease.</AbstractText>
<CopyrightInformation>Copyright © 2020 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Marjot</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Oxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK. Electronic address: Thomas.marjot@ndm.ox.ac.uk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moon</LastName>
<ForeName>Andrew M</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>Division of Gastroenterology and Hepatology, University of North Carolina, North Carolina, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cook</LastName>
<ForeName>Jonathan A</ForeName>
<Initials>JA</Initials>
<AffiliationInfo><Affiliation>Centre for Statistics in Medicine, University of Oxford, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Abd-Elsalam</LastName>
<ForeName>Sherief</ForeName>
<Initials>S</Initials>
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<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Nat Rev Gastroenterol Hepatol. 2020 Dec;17(12):714</RefSource>
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<name sortKey="Zheng, Ming Hua" sort="Zheng, Ming Hua" uniqKey="Zheng M" first="Ming-Hua" last="Zheng">Ming-Hua Zheng</name>
</country>
<country name="Singapour"><noRegion><name sortKey="Wong, Yu Jun" sort="Wong, Yu Jun" uniqKey="Wong Y" first="Yu Jun" last="Wong">Yu Jun Wong</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidStanfordV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000418 | SxmlIndent | more

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Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    CovidStanfordV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:33035628
   |texte=   Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study.
}}

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       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a CovidStanfordV1

This area was generated with Dilib version V0.6.38.
Data generation: Tue Feb 2 21:24:25 2021. Site generation: Tue Feb 2 21:26:08 2021

	Serveur d'exploration sur le Covid à Stanford
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le Covid à Stanford

Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study.

Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study.

Source :

Abstract

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Le document en format XML

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Pour générer des pages wiki